Closer to the science. Closer to the people making it happen.
Two days in London brought researchers and communicators together to talk about how we age, what we can measure, and what you can do about it right now.
This is where those conversations live on: the human studies, the early discoveries, the hard questions, and the research our community helps support.
Explore the conversations by topic. Meet the speakers, read their main points and revisit the 2025 conference.
13 conversations
Read the highlights now. Released recordings will appear here.
Cells, animals & human trials01
SIRT6, DNA repair and lessons from long-lived animals
Professor Vera Gorbunova
University of Rochester
Vera connected the DNA repair seen in long-lived animals and people over 100 with research on DoNotAge.org SIRT6Activator®, from laboratory tests to ongoing human trials.
Main points
Three things to take away
SIRT6 helps cells repair their DNA. Vera explored why especially active versions of this repair protein are linked to longer, healthier lives in some animals and people who live past 100.
In older mice, SIRT6Activator® improved DNA repair, reduced frailty and extended lifespan. Two ongoing human trials in Singapore are now studying its effects in older adults.
Very few fucoidan batches activated SIRT6 in Vera’s lab tests. DoNotAge.org tests every batch of SIRT6Activator® for its ability to activate this DNA repair protein.
Andrei examined how normally silenced elements of our DNA can become active with age, and how that activity may contribute to persistent inflammation.
Main points
Three things to take away
Old virus-like pieces of our DNA can switch back on as we get older. The immune system responds, which can keep low-level inflammation going.
In mouse experiments, blocking these so-called jumping genes reduced inflammation and frailty, and helped the mice live longer.
Andrei’s team is studying ways to keep this under control, including increasing SIRT6 activity and developing drugs that stop these DNA pieces from copying themselves.
Can spermidine support muscle regeneration as we age?
Søren Wilton Kudahl-Laursen
Aarhus University
Can DoNotAge.org Pure Spermidine help older adults repair their muscles? Søren introduced an ongoing muscle-recovery trial and a separate spermidine trial in people with heart disease.
Main points
Three things to take away
Muscle stem cells repair damaged muscle, but they become less effective as we age. The study asks whether spermidine can help them work better.
The muscle trial compares DoNotAge.org Pure Spermidine with a placebo in older adults. Researchers take small leg-muscle samples to examine under a microscope, alongside strength tests.
A separate trial in 200 people with heart disease also uses DoNotAge.org Pure Spermidine, with heart scans and fitness tests to measure its effects.
Recording coming soon
Testing a finding04
Young pig blood in an old rat: does it work?
Nicolás Cherñavsky
Rejuvenation Science Institute · Brazil
A striking claim: tiny particles from young pig blood could rejuvenate older rats. Nicolás’s team set out to see whether they could reproduce the result.
Main points
Three things to take away
The team tested tiny particles taken from young pig blood that an earlier study had linked to rejuvenation in older rats.
Their first attempt did not improve the rats’ grip strength as expected.
After getting missing details from the original researcher, the team planned further mouse and rat experiments to see whether the finding could be repeated.
Recording coming soon
Heart health research05
Why heart disease risk can remain after treatment
Joanna Ward
University of Lincoln · PhD researcher
Joanna is investigating why some people remain at risk of heart attacks and strokes after treatment, and whether the answer lies in aging immune cells and inflammation.
Main points
Three things to take away
Aging immune cells can keep inflammation going, even when blood fats are controlled. Joanna is investigating what drives this response.
She compares immune cells from people with heart disease with cells from healthy donors.
Samples taken before and after treatment will help the team see how inflammation changes, beyond simply lowering blood fats.
Ciara investigated what happens to our DNA during hard exercise, and whether DoNotAge.org Pure Quercetin changes how our cells respond.
Main points
Three things to take away
Ciara used large sets of biological data to investigate how exercise connects to aging and DNA repair.
In a trial with 13 men, each participant completed a hard cycling test with DoNotAge.org Pure Quercetin and with a placebo at different times.
The DNA-damage signal was around 60% lower with DoNotAge.org Pure Quercetin in this trial, alongside changes in DNA repair measures.
Recording coming soon
Animal research07
Could we capture some of exercise’s benefits in a pill?
Dr Constanza Cortes
University of Southern California
Exercise sends messages from our muscles to the rest of the body. Constanza is investigating whether a small protein fragment, called PS18, can reproduce some of those benefits in animal studies.
Main points
Three things to take away
Working muscles release signals that can affect other parts of the body, including the brain.
Her lab is investigating PS18, a small fragment of a protein, as a way to carry some of these muscle-to-brain signals.
The next study compares older mice given PS18, mice exercising on a treadmill and untreated mice. The team will measure memory, frailty and metabolic health.
University of Hertfordshire · University of Lancashire
Can DoNotAge.org Pure Quercetin lower blood pressure? Lindsay and Jonathan shared results from a 20-day trial in healthy adults, comparing DoNotAge.org Pure Quercetin with a placebo.
Main points
Three things to take away
40 adults joined the trial and 38 finished. Participants took either DoNotAge.org Pure Quercetin or a placebo.
The DoNotAge.org Pure Quercetin group saw about a seven-point improvement in systolic blood pressure compared with the placebo group.
The team also reported improvements in blood fats called triglycerides and in self-reported sleep. Other measured outcomes did not change significantly.
Recording coming soon
Funding research09
Why aging research deserves more support
Professor David Weinkove
Durham University · Chair, BSRA
Could studying aging help us tackle several health problems at once? David explained why this research matters, and how early funding helps promising ideas move forward.
Main points
Three things to take away
David’s argument: study the biology of aging to address the shared roots of many age-related conditions.
Human studies need enough participants and enough time to show whether an approach actually helps.
Grants from DoNotAge.org help researchers gather the early results they need to develop larger projects.
Rebecca studied the link between cell division and our immune response, asking whether aging cells lose a natural brake on inflammation.
Main points
Three things to take away
In lab tests, cells that divided faster had a weaker inflammatory response than cells that divided more slowly.
The team found a natural brake on inflammation: proteins that help control cell division also help regulate the immune response.
When cells grow old and stop dividing, that brake may be lost. Rebecca’s team is investigating how this could contribute to persistent inflammation.
Recording coming soon
Human research11
Creatine: beyond muscles, into the brain
Professor Sergej M. Ostojic
Texas Tech University · Scientific advisor
Creatine goes far beyond the gym. Sergej’s video message and Alan’s recap explored cellular energy, brain function and new human research supported by DoNotAge.org.
Main points
Three things to take away
Creatine helps cells manage their energy, which is why researchers are studying it beyond sports performance.
Sergej is studying DoNotAge® Performance in human research on healthy aging, including brain function.
This human trial is studying the effects of DoNotAge® Performance on aging biomarkers, including inflammation, brain function, physical performance and telomere length.
Community & research12
How our community helps move research forward
Alan Graves
Founder & Clinical Research Advisor · DoNotAge.org
Alan brought the science back to everyday life and explained how DoNotAge.org’s members, research funding and ingredients help scientists pursue new questions.
Main points
Three things to take away
DoNotAge.org supports human studies, laboratory research and independent teams checking whether earlier findings can be repeated.
That support includes PhD projects, early-career researchers and teams studying longevity ingredients.
Human trials depend on consistent research ingredients and matching placebos, so scientists can make meaningful comparisons.
Vera Gorbunova, Andrei Seluanov, Andrea Maier & Martin Gnoni
DoNotAge Conference 2025 · New York
Revisit the researchers and conversations that brought our community together in New York, from DNA repair to human trials.
Main points
Three things to take away
Vera Gorbunova and Andrei Seluanov explored DNA repair, long-lived animals and jumping genes.
Andrea Maier discussed clinical research and the SIRT6Activator® human trials.
Martin Gnoni introduced research using DoNotAge.org Pure NMN in people living with HIV.
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15
research projects funded through the BSRA in 2026
YOUR COMMUNITY. REAL RESEARCH.
Backing the questions that deserve answers.
DoNotAge.org supports longevity research through funding, research ingredients and collaborations. Behind every project is a researcher asking a specific question, and a community helping them pursue it.
Through the British Society for Research on Ageing (BSRA), DoNotAge.org funded 15 research projects in 2026. This support helps early-career researchers turn new ideas into studies, from PhD projects to human trials.
Five conference projects
Examples from our wider research support, spanning grants, study funding, research ingredients and collaborations.
01
HUMAN RESEARCH · ULSTER UNIVERSITY
Exercise and the DNA repair response
Ciara Gallardo Juan is investigating what hard exercise does to our DNA, and how quercetin changes the repair response.
